Snappy Touch, a company owned by Noel Llopis who previously has worked on massive console games, is now working on his own start-up. Just a one-person "team" rather than two hundred. He has gone solo and started making iPhone games. He has made an interested presentation at GDC 09 and he shares some knowledge on the process of getting aboard this interesting journey.
Check out the GDC 09 presentation including audio. You can sink the slides manually with the audio pretty easily.